Pfizer

OEM : Pharmaceutical

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New York City, New York, United States

NYSE: PFE

We’re in relentless pursuit of breakthroughs that change patients’ lives. We innovate every day to make the world a healthier place. It was Charles Pfizer’s vision at the beginning and it holds true today. We advance medical innovation and distribute medicines that might not otherwise be available to underserved communities.

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Pfizer’s Edge in the COVID-19 Vaccine Race: Data Science

Date:

Topics: COVID-19

Vertical: Pharmaceutical

Organizations: Pfizer

Pfizer dominated news headlines and family dinner conversations last December when it became the first company to bring a COVID-19 vaccine to the U.S. market. The pharma giant accomplished the feat in record time: less than a year after the disease was first identified.

Integral to that effort was the work of Pfizer’s informatics and digital technology team for its vaccine R&D business. Led by Frank DePierro, this group of researchers crunched and chronicled all of the clinical trial data that led to a green light from the U.S. Food and Drug Administration (FDA), and a safeguard for millions of people.

Read more at IEEE Spectrum

How Pfizer Makes Its Covid-19 Vaccine

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Authors: Emma Cott, Elliot deBruyn, Jonathan Corum

Topics: COVID-19

Vertical: Pharmaceutical

Organizations: Pfizer, BioNTech

“This is where the magic happens.”– Patrick McEvoysenior director of operations and engineering

A rack of 16 pumps precisely controls the flow of the mRNA and lipid solutions, then mixes them together to create lipid nanoparticles.

When the lipids come into contact with the naked strands of mRNA, electric charge pulls them together in a nanosecond. The mRNA is enveloped in several layers of lipids, forming an oily, protective vaccine particle.

Synchronizing eight pairs of pumps is not an ideal solution, but Pfizer engineers chose to scale up existing technology instead of trying to build a larger, unproven type of precision mixing device.

The newly made vaccine is filtered to remove the ethanol, concentrated and filtered again to remove any impurities, and finally sterilized.

Read more at New York Times (Paid)

Why We Can't Make Vaccine Doses Any Faster

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Authors: Isaac Arnsdorf, Ryan Gabrielson

Topics: COVID-19

Vertical: Pharmaceutical

Organizations: Moderna, Pfizer, Johnson & Johnson, Snapdragon Chemistry

The Trump administration deployed the Defense Production Act last year to give vaccine manufacturers priority in accessing crucial production supplies before anyone else could buy them. And the Biden administration used it to help Pfizer obtain specialized needles that can squeeze a sixth dose from the company’s vials, as well as for two critical manufacturing components: filling pumps and tangential flow filtration units. The pumps help supply the lipid nanoparticles that hold and protect the mRNA — the vaccines’ active ingredient, so to speak — and also fill vials with finished vaccine. The filtration units remove unneeded solutions and other materials used in the manufacturing process.

These highly precise pieces of equipment are not typically available on demand, said Matthew Johnson, senior director of product management at Duke University’s Human Vaccine Institute, who works on developing mRNA vaccines, but not for COVID-19. “Right now, there is so much growth in biopharmaceuticals, plus the pinch of the pandemic,” he said. “Many equipment suppliers are sold out of production, and even products scheduled to be made, in some cases, sold out for a year or so looking forward.”

Read more at ProPublica

Politics, Science and the Remarkable Race for a Coronavirus Vaccine

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Authors: Sharon LaFraniere, Katie Thomas, Noah Weiland, David Gelles, Sheryl Gay Stolberg, Denise Grady

Topics: COVID-19, mRNA

Organizations: BioNTech, Moderna, Pfizer

The furious race to develop a coronavirus vaccine played out against a presidential election, between a pharmaceutical giant and a biotech upstart, with the stakes as high as they could get.

Read more at New York Times (Paid)

The story of mRNA: How a once-dismissed idea became a leading technology in the Covid vaccine race

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Author: @damiangarde

Topics: COVID-19, mRNA

Vertical: Pharmaceutical

Organizations: BioNTech, Moderna, Pfizer

The liquid that many hope could help end the Covid-19 pandemic is stored in a nondescript metal tank in a manufacturing complex owned by Pfizer, one of the world’s biggest drug companies. There is nothing remarkable about the container, which could fit in a walk-in closet, except that its contents could end up in the world’s first authorized Covid-19 vaccine.

Pfizer, a 171-year-old Fortune 500 powerhouse, has made a billion-dollar bet on that dream. So has a brash, young rival just 23 miles away in Cambridge, Mass. Moderna, a 10-year-old biotech company with billions in market valuation but no approved products, is racing forward with a vaccine of its own. Its new sprawling drug-making facility nearby is hiring workers at a fast clip in the hopes of making history — and a lot of money.

Read more at StatNews