Continuous-flow Manufacturing

Assembly Line

Pharma Sets a Foundation for Greener API Manufacturing

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✍️ Author: Cynthia A. Challener

πŸ”– Topics: sustainability, continuous-flow manufacturing

🏭 Vertical: Pharmaceutical

🏒 Organizations: Boehringer Ingelheim, W R Grace and Company, Double Rainbow Biosciences

To contribute to the reduction of CO2 and GHG emissions, all drug developers and manufacturers need to seriously consider measures to improve sustainability throughout each phase of their industrial processes, according to Weng. β€œThe pharmaceutical industry is due for a major overhaul in all aspects of its unit operations. Essentially, the pharmaceutical industry should be evaluating sustainable alternatives for all current exercises that rely on fossil fuel inputs,” he sates.

The best time to consider optimal, sustainable production solutions is during the design of the synthetic route to an intermediate/API, notes Martin, because once these processes are validated, it is very challenging to introduce any changes, even if they offer significant improvements in productivity and sustainability.

Read more at Pharmaceutical Technology

How to optimize cleaning in place (CIP) duration?

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πŸ”– Topics: sustainability, equipment cleaning, continuous-flow manufacturing

🏒 Organizations: InUse

Cleaning systems regularly disinfect the entire production lines. They consist of stainless steel tanks, storage tanks, pumps, valves and piping and integrate connections with the production equipment. In a medium-sized factory, the cleaning stations wash up to 250 pieces of equipment per day to avoid contamination from one batch to another (by bacteria or micro-organisms).

When the equipment is being cleaned, disinfected or sterilised, it is not in a position to produce. CIP thus has a direct impact on the uptime rate of production lines. Furthermore, CIPs require large volumes of water, the scarcity of which is becoming increasingly critical looking at the needs of a factory estimated at several tens of thousands of cubic meters per year. Optimising CIPs is therefore an essential lever for any manufacturer who aims to increase the availability of production lines while significantly reducing its water consumption, in other words to achieve eco-efficiency.

Read more at InUse Blog